Recuperar El Pelo - Foro sobre la caída del cabello, experiencias y consejos para tener pelo

Es correcta la interpretación que he hecho de lo leido hasta ahora en el foro.

Es conveniente utilizar algun shampoo con Ketoconazol (2%) dos veces por semana, lo cual sirve para bloquear la enzima AR-5 del tipo que no es eliminada por el finasteride?

El resto de los dias sería bueno utilizar algun shampoo con Pantenon no es así?
Este foro está increible.

Muchas gracias a todos.

Mr. Nacho: no se sabe si realmente bloquea la DHT. De hecho, no está claro cómo funciona. Lo que es seguro, es que funciona. Te dejo acá los mismos estudios que le mostré a Paul para que saques (si sabés un poco de Inglés) tus propias conclusiones.
Lo mismo sucede con el Minoxidil: hay muchas teorías, pero nada absolutamente demostrado. Pero sabemos que funciona.
El shampoo con Ketoconazol tenés que usarlo dos veces por semana y el resto de los días, el que quieras.

It can reasonably be concluded that the clinical efficacy of ketoconazole shampoo in the treatment of AGA is primarily a function of DHT pathway disruption rather than an anti-inflammatory effect. In rat studies ketoconazole caused 5-R inhibition [28]. Furthermore, in humans ketoconazole has also been shown to inhibit the binding of 5-R to sex hormone globulins [29]. These clinical studies suggest that ketoconazole like finasteride may inhibit the production of DHT. Unlike finasteride ketoconazole has been shown to bind to human AR [30]. Thus, the effect of ketoconazole on the DHT pathway may be two-fold: inhibition of DHT and/or inhibition of DHT binding to AR. Either or both of these properties would result in reduced incidence of DHT binding to AR and inhibiting the pathway that leads to the miniaturizing of hair follicles.

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

California College of Podiatric Medicine, 371 Columbus Avenue, San Francisco, CA 94133, USA.

Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat AGA. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of AGA. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat AGA.

PMID: 14729013 [PubMed - indexed for MEDLINE]

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

Un abrazo!

Ketoconazol es la marca del champu o es un elemento que lleva el mismo?

Un saludo .

Es el "elemento" que lleva.

Algunas marcas:

España: Fungarest
EEUU/México: Nizoral
Argentina: Triatop

Abraxo Mr. Poteitouu

En España también tenemos Ketoisdin: Ketoconazol 2%

BUENO KIERO SABER SI ESTE SHAMPOO, SIRVE PARA LA CASPA TAMBIEN , ES DECIR CUANDO LO EMPEZE A USAR ME RESOLVIO EL PROBLEMA (PEKEÑAS PLAKITAS BLANCAS) PRO AHORA DESCUBRI CASPA FINA

SIRVE PARA ESTE FIN TAMBIEN ?

Claro. Si tenés caspa normal, en dos semanas elimina todo. Es una "maravilla".

¿vale para la grasa y paa que no caiga el pelo?

qeu marca buena hay de shampu con ketoconazol ademas del triatop?? sirve para la grasitud del cabello???

Cris escribió:¿vale para la grasa y paa que no caiga el pelo?

Cris: sirve para evitar la caída cuando la causa es Androgénica. En el caso de la grasa, funciona a largo plazo. Si tu problema es la seborrea (grasa) es mejor que uses un shampoo antiseborreico (H&S Citrus).

Achus escribió:qeu marca buena hay de shampu con ketoconazol ademas del triatop?? sirve para la grasitud del cabello???

Achus: Orifungal, Quadion y Eumicel. Para la grasitud sirve a largo plazo. A corto plazo, tenés que usar también un antiseborreico.

Besos, abrazos y alegrías.

como que para la caida del cabello? es como el minoxidil? que es lo que hace? la verdad pense que habia dos soluciones para el AGA (minox y finasteride) pero un shampoo?

Peladao, fijate los estudios que están arriba, en el segundo mensaje de esta misma página. En resumidas cuentas, el Ketoconazol tiene un rendimiento final similar al del Minoxidil al 2%. Hay que ser paciente, porque los cambios aparecen recién a los nueve meses (como un parto), pero que funciona, funciona.

Cuanto cuestan cualquiera de los que mencionaste?? Quadion orifungal o eumicel???? y donde se consiguen con descuento y cual de los 3 es el mas efectivo??? Gracias....

Los precios son estos: (Ketoconazol 2%)
Socosep $ 32
Quadion $ 25
Orifungal $ 31
Eumicel $8

Yo uso Quadion u Orifungal. De todos modos, el Eumicel es exactamente lo mismo. Lo importante es que tenga Ketoconazol 2%.

La efectividad es la misma en cualquiera de ellos.

Entonces me conviene comprar el Shampoo Ketoconazol qeu hace HR qeu vale 20 mangos y es antiseborreico.