- Mar May 19, 2015 7:31 pm
#467799
Comparación entre RU y CB, interesante
RU 58841
Originally studied by the French pharmaceutical company Roussel-Uclaf, hence the “RU”, it has been primarily studied for the treatment of MPB and has a very impressive potential: it is one of the most potent and effective anti-androgen known at the moment, and display a very high affinity and selectivity to the androgen receptors. It basically act like Spiro, it is not a “DHT killer” but binds much more aggressively than spiro to androgen receptors, preventing DHT binding. It has actually been sold for a short period of time in Japan and Europe, before being dropped for the even more promising CB 03 01.
Because it blocks both type of DHT receptors, it should be efficient against any type of AAS. The drawback of the compound actually comes from its efficacy: it readily passes the transdermal barrier and is quite hardy, which mean that the RU that don’t bind to the receptors in the scalp will continue their journey and bind to other receptors. It can therefore give typical anti-androgen sides, although the users reporting these sides admit that they are sensitive to anti-androgen and that the sides are much less than what they experience with fina / duta.
Another issue with RU is its relatively short shelf life. It is sensible to oxygen and temperature and doesn’t stay potent very long once in solution. For this reason, the raw should be kept in a sealed bag in a freezer and batches of 5 to 10 applications should be prepared one at a time.
Finally, it is a bit pricey. But beyond the above mentioned issues, it is the most effective and potent anti-androgen money can buy at the moment and beat flat any other topical compound.
CB 03 01
Well, with all these properties, why isn’t RU 58841 already available at your local pharmacy? Because CB 03 01 is even more promising.
It displays the same aggressive and selective anti-androgen properties than RU 58841, with a few extra ones that make it even better:
- It is much more stable than RU, drastically extending its shelf life
- It is cheaper
- It rapidly degrades into a neutral compound once it enters the body. It means that the CB that doesn’t bind to your hair follicles will lose its anti-androgen properties before it reaches other organs. It makes it virtually side-effects free
CB is under development for a while now, by Cosmo, and has finished the final clinical studies case for the 1% concentration that will be prescribed as an anti-acne cream. It should be available early next year. The 5% concentration, developed for hair loss (1% is not strong enough for this purpose), is in Phase 2. Needless to say, it is eagerly awaited by the thousands of men suffering from MPB but also by the gear users who wish to see their hairline surviving their next cycle.
Just like RU, CB can be bought in raw powder form from various websites, however it is useless for the average Joe. The problem with CB is the carrier, RU is readily solvable in alcohol but it’s a whole different story with CB, actually a solid part of the research work was carrier-related. To cut it short, even if you get CB you shouldn’t be able to make a solution that will effectively make it through your scalp, so in my book it is better to wait for the final product release.
Plenty of information about the compounds, and especially about RU since it is around for a longer time than CB, are available on the web, if you’re interested in them let me know and I’ll point you in the right direction.