A ver ke opinan sobre este informe sobre usar una aplicacion diaria mas 0.01% de Tretinoin.
Tretinoin segun Wikipedia es esto:
Tretinoin is the acid form of vitamin A and so also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel (brand name Retin-A). It is also used to treat acute promyelocytic leukemia (APML).
The Efficacy of 5% Minoxidil vs. Combined
Topical Agent of 5% Minoxidil and 0.01%
Tretinoin on Male Pattern Hair Loss: A
Randomised Comparative Clinical Trial
Department of Dermatology, Seoul National University
College of Medicine, Seoul, Korea
Topical minoxidil 5% solution has been widely used to stimulate
new hair growth and to help stop the hair loss successfully in men
with male pattern hair loss (MPHL). Nevertheless, it is not easy for
the patients to keep applying the solution twice a day regularly. The
purpose of this 18-week, double-blind, randomised study was to com-
pare the efficacy and safety of the treatment of combined solution
of5% minoxidil and 0.01% tretinoin once a day with conventional
topical 5% minoxidil therapy applied twice a day in the treatment of
MPHL. A total of 29 male patients (25–50 years old) with MPHL
(Hamilton type III–V) were randomly assigned to apply 5% minoxi-
dil twice daily or the combined agent once a day at night using vehi-
cle placebo in the morning. The efficacy parameters were (1) changes
in total hair count, mean hair thickness and linear growth rate mea-
sured by phototrichogram and (2) the patient and investigator subjec-
tive assessment of change in scalp coverage. After 18-weeks of
therapy, significant increases in the all macrophotographic variables
of total hair count, mean hair diameter and linear growth rate were
shown in both treatment groups. Moreover, the 5% minoxidil and the
combined agent groups also demonstrated similar improvement in the
subjective global assessment by patient and investigator. There was no
statistically significant difference between the treatment groups. The
occurrence of side effects like pruritus or local irritation was similar
in 5% minoxidil group (5 of 14 subjects) and the combined agent
group (5 of 15 subjects). In conclusion, the efficacy and safety of
combined 5% minoxidil and 0.01% tretinoin once-daily treatment
would be equivalent to the conventional 5% minoxidil twice-a-day
therapy for treatment of MPHL.
Aca esta el link del pdf.
content.karger.com/ProdukteDB/produkte. ... =92842.pdf