[sanjuan23]

Hola buenas noches!,

Hace 2 meses y algo que me registré en el foro, y hace 2 meses que comencé mi tratamiento con Minoxidil, con Viñas al 5% 2 veces al día... por la mañana y por la noche a ser posible (y cuando no era posible, pues al menos una diferencia de 4h. entre aplicación)
Tengo AGA, y cabello graso.. en 24h. le tngo sucio y me le tngo q lavar si o si

Estuve usando Finpecia (Finasteride), durante.. 7 meses mas o menos, y aparte que me producía impotencia sexual, menos erecciones, etc.. no notaba que mejorara/estabilizara mi pelo.

Pero en estos 2 meses que llevo usando Minoxidil Viñas (no quiero decir q esta marca sea mejor q otra, no he probado otras).. me he quedado asombrado la verdad, noto una leve mejoría, sobre todo la semana pasada al salir de la peluqueria, no noté "tanto claro" en la coronilla.

Imagino que a unos les irá bien, a otros no les hará efecto.. a otros les desesperará el shedding.. (yo no descarto que tenga shedding al 3ºmes :/ ) pero es la mejor solucion que he probado, aunq solo haya probado esto, finasteride, y el champú ketokonazol..
Pero os animo a continuar, aunq me resulta 1 poco coñazo las 2 aplicaciones al dia.. es malo reducir a 1 aplicacion diaria? imagino que no habrá tanto progreso..

Tengo una pregunta sobre el Ketoconazol q no se si me podriais resolver aqui..
Fui a un médico, y me dijo que el Ketoconazol no sirve para AGA, que es solo para curar los Hongos del cabello.. y le dije que sirve también para los cabellos grasos, y me decía que no..
Por ello no se si seguir con ello o q.. Me lo estoy dando 2 veces por semana.

Muchas gracias y espero os sirva de ayuda!
Animo!

[Nico]

Hola como estas !

Antes que nada decirte que como minimo entre cada aplicacion tiene que pasar 8hs.
Me alegro que te este funcionando bien el minoxidil al iniciio que es cuando mas cuesta, pero se cauto, te lo digo porque por ahi si esto se estanca un poco despues vas a creer que no funciona y no es asi, hay que tratar de estar tranquilo con estos tratamientos y no desesperarse.
El champo con ketoconazol es un antifungico, antiseborreico y antiandrogeno suave (funciona como el minox 2% mas o menos)

Acá te dejo un estudio donde explica como funciona en casos de alopecia androgenética:

It can reasonably be concluded that the clinical efficacy of ketoconazole shampoo in the treatment of AGA is primarily a function of DHT pathway disruption rather than an anti-inflammatory effect. In rat studies ketoconazole caused 5-R inhibition [28]. Furthermore, in humans ketoconazole has also been shown to inhibit the binding of 5-R to sex hormone globulins [29]. These clinical studies suggest that ketoconazole like finasteride may inhibit the production of DHT. Unlike finasteride ketoconazole has been shown to bind to human AR [30]. Thus, the effect of ketoconazole on the DHT pathway may be two-fold: inhibition of DHT and/or inhibition of DHT binding to AR. Either or both of these properties would result in reduced incidence of DHT binding to AR and inhibiting the pathway that leads to the miniaturizing of hair follicles.

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

California College of Podiatric Medicine, 371 Columbus Avenue, San Francisco, CA 94133, USA.

Dihydrotestosterone (DHT) binding to androgen receptors (AR) in hair follicles is commonly accepted as the first step leading to the miniaturizing of follicles associated with androgenetic alopecia (AGA). Testosterone is converted to DHT by the enzyme 5alpha-reductase. Finasateride a 5alpha-reducase inhibitor blocks the production of DHT and is currently used to treat AGA. The inhibition is not complete but a reduction of DHT systemically and in the scalp is accomplished. Ketoconazole has been clinically shown to be effective in the treatment of AGA. In this paper, evidence is presented to support the hypothesis that ketoconazole 2% shampoo has a local disruption of the DHT pathway. It is proposed that using ketoconazole 2% shampoo as an adjunct to finasteride treatment could lead to a more complete inhibition of DHT and thus better treat AGA.

PMID: 14729013 [PubMed - indexed for MEDLINE]

March 04, 2001 - American Academy of Dermatology Meeting - Washington DC - Scientists working for McNeil, makers of Nizoral anti-dandruff shampoo, presented the findings of a study done on 1% Nizoral shampoo which has good news for hair loss sufferers. It has long been known that 2% prescription Nizoral has beneficial effects on Androgenic Alopecia (MPB). It however has been unclear whether the same benefits can be obtained by using the non-prescription 1% version.
In the study presented (see below), one hundred male volunteers with mild to moderate dandruff and somewhat oily scalp, were using, in a double-blind fashion, either a 1% Nizoral shampoo or a 1% zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up in the study shows that the hair diameter gradually increased with Nizoral use (+8.46%) over a 6 month period, whereas the diameter showed a trend to decrease with zinc pyrithione use over the same period (-2.28%). The sebum excretion rate was reduced with Nizoral (-6.54%) while it increased with zinc pyrithione (+8.2%) over the same period of time. The number of hair shed over a 24-hour period was reduced by 16.46% with Nizoral and 6.02% with zinc pyrithione after 6 months. Finally, the percentage hairs in anagen phase increased by 6.4% and 8.4% respectively during the study time.

The results are similar to a previous study done on 2% prescription strength Nizoral where it was shown that use of 2% Nizoral yielded a 7% average increase in hair shaft diameter similar to what was achieved by the control group using 2% Minoxidil and a non-medicated shampoo.

So for any hair loss sufferer, this research clearly indicates that using 1% or 2% Nizoral 2-3 times per week, will have positive effects on hair growth as well as controlling dandruff. It is still unclear at this time whether it's the anti-fungal properties or the anti-androgenic properties of Ketokonazole (active ingredient in Nizoral) thats responsible for the hair thickening effects, however because of the decrease in sebum rates as well, it is the authors opinion that the results are due to the anti-androgenic properties of Ketokonazole.

Saludos !!